The purpose of sperm aneuploidy using the FISH method is to determine the percentage of sperm with an abnormal number of chromosomes. Abnormalities include double-presence or absence of individual chromosomes, or the doubling of the entire chromosome set.
The reason for the FISH test is to determine the future risk of chromosomal defects in the future embryo, whether after natural fertilization or IVF.
The examination is suitable for patients who are carriers of chromosomal defects, cancer patients, or patients with repeated failed IVF cycles.
The patient hands over a sample in the sampling room, similar to the classical spermiogram. The FISH method itself is based on the detection of fluorescently labelled DNA sections specific for the selected chromosomes. The sample is then evaluated under the microscope where the individual colour signals correspond to the type and the number of particular chromosomes.